Production of Transfusable Red Blood Cells from Stem Cells
نویسندگان
چکیده
منابع مشابه
Gene Expression Profile of Adherent Cells Derived From Human Peripheral Blood: Evidence of Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) provide a novel option in cellular therapy and tissue engineering. Recent studies indicated that it is possible to obtain MSCs from peripheral blood by attachment ability to plastic surface. To evaluate adherent cells derived from peripheral blood, their expression profile and surface markers were investigated. The results of RT-PCR indicated that these cells expre...
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Purpose: This study was carried out to isolate mesenchymal stem cells from full-term cord blood and to differentiate these cells into osteoblastic cells. Materials and Methods: It this study, mesenchymal stem cells were isolated from cord blood and expanded by being cultured in the flask several times. First, the cord blood monoeuc1earcells were separated by ficoll - Hypac before they were cul...
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We have previously shown that human embryonic stem cells can be differentiated into embryonic and fetal type of red blood cells that sequentially express three types of hemoglobins recapitulating early human erythropoiesis. We report here that we have produced iPS from three somatic cell types: adult skin fibroblasts as well as embryonic and fetal mesenchymal stem cells. We show that regardless...
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Several lines of evidence have reported that mouse ESCs can successfully differentiate into primordial germ cells (PGC) as well as into mature male and female gametes. Human ESCs and adult stem cells (ASCs) can also differentiate into PGCs. Differentiation of ESCs into germ cells of various stages seems to be a spontaneous and quick process, probably due to the nature of ESCs themselves and the...
متن کاملMesenchymal Stem Cells as a Feeder Layer Can Prevent Apoptosis of Expanded Hematopoietic Stem Cells Derived from Cord Blood
Umbilical cord blood (UCB) has been used for transplantation in the treatment of hematologic disorders as a source of hematopoietic stem cells (HSCs). Because of insufficient number of cord blood CD34+ cells, the expansion of these cells seems to be important for clinical application. Mesenchymal stromal cells (MSCs), playing an important role in HSCs maintenance, were used as feeder layer. Apo...
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ژورنال
عنوان ژورنال: The Korean Journal of Blood Transfusion
سال: 2016
ISSN: 1226-9336,2383-6881
DOI: 10.17945/kjbt.2016.27.3.209